Dr. McLaughlin's work has been recognized in a variety of prestigious journals.

What are Acetogenins?

Acetogenins are active compounds that affect the production of ATP (Adenosine Triphosphate) in the mitochondria (the powerhouse) of the cell. ATP is our cells’, and hence our body’s, major source of energy. Acetogenins modulate the production of ATP.

How do they work?

The energy-inhibiting properties of acetogenins help regulate specific cells in four ways:

1. Modulates the production of cellular energy.

All cells use energy. Specific cells require significantly more energy than other cells. The major source of energy for cells comes in the form of ATP. Because acetogenins modulate the production of ATP in the mitochondria, specific cells, which are programmed to replicate and metabolize up to 17 times the speed of other cells, do not thrive in the presence of acetogenins. Certain cells are particularly susceptible to the effects of acetogenins, while hearty cells remain unaffected.

2. Helps modulate the growth of blood vessels near specific cells.

In order for cells to thrive and grow, they need a supply of food and oxygen. Blood vessels form to supply this need. This new vessel growth (angiogenesis) requires ATP; thus, ATP reduction affects the growth of new vessels that nourish the concentrations of specific cells.

3. Enhances the effectiveness of common medical treatments for cellular damage.

Abnormal cells are often able to recognize familiar chemicals. This often makes them resistant to continued common treatments because when the chemical enters the cell, the cell pumps the chemical back out before it delivers its desired effect. This pump is dependent upon ATP. The pump will stop when it supply of ATP dwindles. If the chemical can stay in the cell, the treatment will be more effective.

4. Reduces the amount of materials available to allow for cellular division.

ATP is an essential precursor to DNA and RNA—genetic material or the cell’s blueprints then dictate all the actions and structure of the cell. Without duplication of these substances, cells cannot divide. Lowered levels of ATP—an essential building block of these nucleic acids—affect rapid cell proliferation [“tumors”].

Where are they found?

The most potent available source of acetogenins is the pawpaw tree (Asimina triloba). This tree is native to the eastern United States. Though acetogenins are found throughout the paw paw tree, the twigs contain the most concentrated amount of acetogenins, especially when they are harvested when they are most biologically active. Watch this section of our website for more information about the paw paw tree and NSP products containing paw paw.

Copyright © 2003 Nature's Sunshine Products. Reprinted with permission.

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