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Dr. McLaughlin is professor emeritus of pharmacognosy in Purdue University School of Pharmacy and Pharmacal Science, but says he was glad to leave Purdue to become a part of Nature's Sunshine Products' science team in part because because at NSP's Science Department he would have access to scientific equipment that was not available to him at Purdue. He has been studying compounds in the bark of the pawpaw tree for more than 25 years. |
The pawpaw tree may bear new fruit for scientists seeking ways to fight cancer.
Jerry McLaughlin, professor of pharmacognosy, and former doctoral student Nicholas Oberlies have found compounds in the bark of the tree that have shown preliminary success in fighting some drug-resistant cancers.
The pawpaw compounds not only are effective in killing tumors that have proven resistant to anticancer agents but also seem to have a special affinity for such resistant cells.
"Multidrug-resistant cancer is hard to treat because the cancer cell has developed a mechanism to get around the anticancer agent," McLaughlin says.
"Tumor cells that survive chemotherapy treatments often recover with increased resistance to the agent used in the original treatment program as well as to other related drugs."
The effect of the pawpaw compounds on drug-resistant cells has been studied only in laboratory cultures and will require additional study in animals before it can be tested in humans. [Since this article was written, paw paw was demonstrated significantly effective against several different types of "cellular abnormalities" in a clinical study involving over 100 subjects with varying stages of tumor development.]
Oberlies earned his Ph.D. in 1997.
A patent on the use of the compounds in treating drug-resistant cells is pending.
Stories by Susan Gaidos and Kate Walker, Purdue News Service, and Steve Tally, PNS and Agricultural Communication Service
Source:
www.purdue.edu/PER/S98Perspective.research.html
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