This article clearly demonstrates that it has been at least fourteen
years since the
Food and Drug Administration (may their name be blotted out) was
warned by respected authority that there is significant reason to believe
that a large number of American adults and children have been infected,
and continue to be infected, by contaminated vaccines derived from
infected monkeys used in the production of those vaccines. To our
knowledge, the FDA has not yet acted on this warning.
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The Human Stealth Virus
and Its Animal Origin
THE VACCINE REACTION
When it happens to you or your child, the risks are
Vol.1, No.4, Sept./Oct. 1995, Barbara Loe Fisher, Editor
Published bimonthly by the National Vaccine Information
To The Reader:
Since the beginning of September, I have been engaged
in a remarkable dialogue with a scientist at the University of Southern
California whose work I became aware of after reading an article
published in the "Riverside Press" on August 28.
Although the content of the September October issue of
"The Vaccine Reaction" had already been scheduled, I came to the
conclusion that this story was of such importance and potentially
impacts upon so many individuals suffering from unexplained
neurological, psychiatric and autoimmune disorder symptoms, that the
entire issue should be devoted to covering it.
I do not believe the significance of this
research should be underestimated or minimized and, in the
interest of public health and safety, expect that the Food and Drug
Administration and Centers for Disease Control officials responsible for
insuring the public health and safety will take their responsibilities
seriously and act quickly to support continuation of this research to
confirm or disprove these scientific findings. Failure to act
now could jeopardize the health and well being of every baby born and
every child and adult who may already be infected with an atypical
cytopathic virus they contracted through exposure to contaminated
vaccines or exposure to infected blood or body fluids.
Discovery of an Atypical Virus Infecting Humans Linked to Viral
Vaccines Produced on Monkey Tissues
In what could be one of the most
important scientific discoveries of this decade, an award winning
pathologist and immunologist at the University of Southern California, W.
John Martin, M.D., Ph.D., has discovered an atypical virus infecting both
children and adults who are exhibiting neurological, psychiatric and
autoimmune disorder symptoms with diagnoses including chronic fatigue
syndrome, fibromyalgia, depression, schizophrenia, anxiety disorder,
seizures, developmental delays, autism, lupus, multiple sclerosis,
Alzheimer's, Parkinson's, unexplained encephalopathy and chronic
Martin and his colleagues at USC's
Infectious Diseases and Molecular Pathology Laboratories have been
meticulously culturing out stealth viruses from patients for the past
eight years and, in a stunning development earlier this year, successfully
identified one of the viruses as being of African green monkey origin by
using DNA sequence analysis. Kidney tissues from African green
monkeys have been used to make the live oral polio vaccine (OPV) as well
as other viral vaccines during the past three decades.
You Can Be Infected And Not Be Sick
A distinctive feature of the virus
Martin and his colleagues has characterized is that it belongs to a novel
class of atypical cytopathic viruses (capable of causing pathologic
changes in cells), which they refer to as "stealth viruses" because they
have the ability to evade detection by the body's cellular defense
mechanisms and appear to lack the antigens which normally cause an
inflammation typical of most infections that damage cells and body
The monkey-related stealth virus they
are studying is a cytomegalovirus belonging to the herpes virus family
that causes an atypical viral infection of the brain - a "stealth virus
encephalopathy" - that can produce a spectrum of disease symptoms without
evoking an inflammatory response. Therefore, a person can also become
infected and can carry and transmit the virus to others without exhibiting
The stealth virus can remain dormant in
an infected but symptomless individual throughout life. However, in some
infected individuals the virus can become active, triggered perhaps by
significant mental or physical stress, and go on to cause atypical
responses to normal sensory input into the brain resulting in sudden,
unexplained neurological symptoms.
It is thought that a stealth virus can
be transmitted, like HIV, hepatitis B or polio, by coming into direct
contact with the virus (such as ingesting or being injected with a
contaminated vaccine) or coming into contact with the blood or
body fluids of an infected individual.
Chronic Fatigue Syndrome, Depression, Encephalopathy
In an August 1994 article published in
American Journal of Pathology. Dr. Martin and his colleagues describe how
over a three year period they repeatedly cultured out an atypical
cytopathic virus from a 43-year old woman who became suddenly ill in 1990
with a sore throat, muscle aches, intense headaches, fever and eventually
was hospitalized with suspected encephalitis/meningitis - although all
tests came back negative. She continued to feel ill and eventually was
diagnosed with chronic fatigue syndrome accompanied by severe headaches,
insomnia, memory loss and brain dysfunction. In that same article, Martin
et al confirm that they also cultured out the same atypical virus
from a patient with severe encephalopathy who had a four year history of
Unstable Virus Mutates Easily
Several months later in an October 1994
article published in the College of American Pathologists magazine CAP
Today, Dr. Martin explained that "stealth viruses have been derived from
herpes viruses (and possibly other viruses) by a process of major gene
deletions and mutations. These genetic changes presumably account for the
lack of an appreciable inflammatory response and for the wide host range
of infectable cells."
Although he acknowledges that
neurological, psychiatric and immune system disorder symptoms can have a
variety of causes, just as stealth viruses present in animals and humans
can have different origins, Martin is pursuing the particular stealth
virus he has identified because he has been able to scientifically prove
its genetic relationship to African green monkey cytomegalovirus.
"The animal stealth virus we have
identified has an unstable genome and it mutates easily. It doesn't grow
very well in culture and so it can be easily overlooked during testing. Of
concern is the fact that, when you introduce unstable animal stealth
viruses into man, there is a risk of recombinant (the formation of new
combinations of linked genes) events occurring which can produce new kinds
of diseases. Now that we have the technology, it is very important to act
immediately to screen viral vaccines for stealth viruses, to determine who
is already infected and to develop therapies to interrupt activation as
well as treat those who already have symptoms."
Unexplained Seizures, Developmental Delays, MS, Lupus,
In the CAP Today article, Dr. Martin
reports on several cases including a 19 year old boy who had suffered
unexplained severe brain damage at age 17 and a six month old infant with
unexplained seizures and delayed neurological development. Both patients
had tested negative for brain inflammation but tested positive for stealth
In another case Martin describes several
more patients who tested positive for stealth virus infection such as the
woman who had been diagnosed by various doctors as having multiple
sclerosis, lupus, and cerebral pseudotumor, and a woman who was diagnosed
as schizophrenic at age 19, then manic depressive with delusions. Four
years later she experienced a near-fatal encephalopathy with cardiac
arrest and has remained in a vegetative state for five years.
In one family being studied by Martin
and his colleagues, four family members have tested positive for stealth
virus infection including a husband and wife diagnosed with chronic
fatigue syndrome, the wife's mother diagnosed with atypical Parkinson's
disease, and a son diagnosed with schizophrenia.
All of these patients are now
being diagnosed as suffering from stealth virus encephalopathy.
Autistic Child Infected with Stealth Virus
In a letter published in early 1995 in
the Journal of Autism and developmental Disorders, Dr. Martin described
the case of a 10 year old boy who began exhibiting autistic behavior at
age one, was diagnosed as classically autistic at age four and currently
exhibits ritualistic and aggressive behavior that is so difficult to
control that he has been institutionalized.
He has repeatedly tested positive for
infection with the stealth virus and Martin concluded, "Repeated culturing
a stealth virus from an autistic patient does not establish that the virus
is responsible for the patient's illness. Symptoms of autism are, however,
consistent with impaired neurosensory functions due to persistent viral
infection and previous attempts to demonstrate viruses in such patients
may have failed to detect stealth viruses."
DNA Sequencing of Virus Leads to Monkey Origins
In an article published in the July 1995
issue of Clinical and Diagnostic Virology, Martin and his colleagues
describe how they conducted DNA and amino acid sequence comparisons
showing that the stealth virus isolated from a patient with chronic
fatigue syndrome (CFS) was "more closely related to the Colburn strain of
simian cytomegalovirus than to cytomegalovirus of either human or rhesus
monkey origin or to any other sequenced herpes virus."
These comparisons were confirmed using
polymerase chain reaction (PCR). The scientists concluded that "the
findings implicate the African green monkey as the probable source of the
virus isolated from this CFS patient." They go on to suggest that
"the potential introduction of pathogenic viral variants into humans
through the use of African green monkey-derived cell lines in live
virus vaccine production should be evaluated."
Animals Get Sick, Too
Martin and his colleagues have performed
more than 1,000 cultures in their eight-year study of the stealth virus
and have found that not only is there a clustering of culture positive
findings in members of the same families, but that there is also a pattern
of unexplained neurological illnesses in the pet dogs and cats of patients
diagnosed with chronic fatigue syndrome, indicating that the stealth virus
may also be capable of infecting and being carried by animals.
Testing this hypothesis, the scientists
have isolated the monkey-related stealth virus from a culture-positive
human patient and injected it into cats. In an article to be published in
the December issue of Pathobiology, they report their remarkable findings
of what happens to the cats after they have been infected with the Virus.
The Money Has Run Out
A casualty of the budget cuts that are
hitting California and other localities across the country, the minimal
funding that has helped USC's Infectious Diseases and Molecular Pathology
Lab conduct stealth virus research has now been exhausted. The Lab has
been forced to drastically cut back on its research linking the
proliferation of atypical neurologic, psychiatric, and immune system
disorders in children and adults to the detection of an atypical
cytomegalovirus whose genetic code is almost identical to that of a virus
that is commonly present in the kidney tissues of the African green monkey
and could have, therefore, been inadvertently transmitted to
humans during the production of the oral polio vaccine.
Committed to continuing their research
because they know their discovery has the potential to save lives, Martin
and his seven colleagues have continued to work without pay for the past
month in an effort to keep USC's lab open.
An Appeal to the FDA
Dr. Martin, who is professor of
pathology and director of USC's Infectious Diseases and Molecular
Pathology Lab, has received numerous awards, scholarships and fellowships
during his 30-year career as a distinguished scientist at Harvard,
University College in London, University of Sydney in Australia, NIH, Food
and Drug Administration, and the National Cancer Institute.
In June, Dr. Martin and S. Zaki
Salahuddin, Ph.D., Li Chang Zeng, M.D., Khalid Ahmed, M.T., Jing G.
Seward, M.D., John-Carl Olsen, Inderjit Singh Seehrai, M.D., and Mark
Nowicki, Ph.D., applied to the FDA for a 6-month grant to:
Determine the prevalence of simian
cytomegalovirus derived stealth viral infection in humans.
They are proposing a simple, quick and cost-effective way to do that by
performing serological, polymerase chain reaction (PCR) and viral
culture testing of blood and lymphocyte samples already stored in the
National Heart, Lung and Blood Institute at NIH which were obtained
during the federally funded Transfusion Safety Study (TSS) conducted in
The University of Southern California acted as the prime contractor for
the TSS, a study which was conducted because of the fear that blood
products were contaminated with viruses, including HIV. The goal of the
Transfusion Safety Study was to try to determine the prevalence of viral
infections, including HIV, in well defined populations in the U.S.
In addition to the proposal to test the TSS samples for stealth virus
infection, Martin has already obtained permission from the Los Angeles
County - University of Southern California Medical Center's
Institutional Review Board to test blood and fluid samples stored in
their archives if funding can be obtained to do it. The scientists
estimate that if they tested a total of 250 blood samples from both of
these sources, it would be adequate to make an initial scientific
determination of the scope of stealth virus presence in the U.S.
To screen monkey colonies used for the
production of viral vaccines for the presence of stealth viruses.
They are proposing that immediate steps be taken to stop using monkeys
that are infected with the stealth cytomegalovirus to make vaccines by
culturing blood from each monkey designated as a source of kidney tissue
for vaccine production including performing PCR and viral cultures to
test for the presence of stealth virus.
Act Now to Screen Vaccines and Blood Supply
Martin and his colleagues concluded
their appeal to the FDA to give them a six-month grant to fund their work
with these words: "FDA is responsible for the safety of biological
products including vaccines and the Nation's blood supply. As described in
the Appendix to this proposal, stealth viruses have been associated with
severe neurological illnesses. It is imperative that the issue of the
potential prior transfer of pathogenic stealth viruses into humans be
addressed. This proposal will provide much needed data to assess the
overall prevalence of stealth viral infection and the proportion of these
infections attributed to a cytomegalovirus derived stealth virus of
African green monkey origin. The proposal is also an important step
towards ensuring that future vaccine lots are free of stealth viruses. The
findings will also have bearing on the possible need to screen blood
donors for the presence of stealth viruses."
Therapies Are Being Developed
A major goal of Martin's research is to
not only identify individuals who are infected but to develop antiviral
therapies which can interrupt the activation of a stealth virus in
infected but symptomless individuals as well as help those who are already
exhibiting mild to severe symptoms.
Martin maintains that stealth viruses,
whether of animal or human origin, may also play a role yet to be
identified in other illnesses such as arteriosclerosis, autoimmune thyroid
disease, gastrointestinal and kidney disease, infertility and cancer. He
and his colleagues are working on isolating a genetically engineered
component of the stealth virus which an infected individual could take
orally to inhibit its activation and growth.
NVIC Will Operate Registry and Support Network
In a continuing effort to collect
information from parents of children as well as adults who have been
adversely affected by vaccines, the "National Vaccine Information Center"
will expand the scope of its 14-year old vaccine reaction registry and
begin collecting information and providing referrals to those who are
suffering from unexplained neurological, psychiatric and autoimmune
disorder symptoms that are potentially related to stealth virus infection.
Parents of children or adults who are
exhibiting symptoms such as those described in this newsletter and who
want to be included in NVIC's registry will be sent a questionnaire to
fill out. To register and obtain a questionnaire, write to Vaccine
Reaction Registry, NVIC, 512 W. Maple Ave., Suite 206, Vienna, VA 22180.
Please include a $5 donation to cover processing and data entry costs Once
the questionnaire is returned, NVIC can offer assistance to registrars on
how they can follow-up and be tested for stealth virus infection and,
additionally, determine whether they should or would like to consider
becoming part of the stealth virus research laboratory test database being
developed by the USC lab.
[Before you jump
in and try to register for this project,
remember that this article was published in 1995.
This is just an informational reprint.]
NVIC is also expanding its 14-year old
support network to help stealth virus positive individuals to communicate
with each other to exchange information as well as become active in the
promotion of research to develop therapies and prevent infection.
Reprinted in Issue No. 87 of the "Leading
Edge International Research Journal "
Leading Edge Research Group, P.O. Box 7530, Yelm, Washington 98597 USA